Institute for Ophthalmic Research

Position

Director, Institute for Ophthalmic Research

Contacts details

Address

Centre for Ophthalmology
Institute for Ophthalmic Research
Roentgenweg 11
72076 Tuebingen

Phone, fax

Phone+49 7071 29-84021
Fax+49 7071 29-4560

WWW

Emailmarius.ueffing@uni-tuebingen.de
 
 

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Selected publications

Boldt, Dorus A. Mans, Jungyeon Won, Jeroen van Reeuwijk, Andreas Vogt, Norbert Kinkl, Stef J. F. Letteboer, Wanda L. Hicks, Ron E. Hurd, Jürgen K. Naggert, Yves Texier, Anneke I. den Hollander, Robert K. Koenekoop, Jean Bennett, Frans P.M. Cremers, Christian J. Gloeckner, Patsy M. Nishina, Ronald Roepman, Marius Ueffing. (2011). "Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis", Journal of Clinical Investigation, in press

Del Río P, Irmler M, Arango-González B, Favor J, Bobe C, Bartsch U, Vecino E, Beckers J, Hauck SM, Ueffing M. (2011). "Osteopontin from Müller glial cells promotes photoreceptor survival in the Pde6b(rd1) mouse model of retinal degeneration", Glia. 2011 May;59(5):821-32.

Griciuc A, Aron L, Roux MJ, Klein R, Giangrande A, Ueffing M. (2010) "Inactivation of VCP/ter94 suppresses retinal pathology caused by misfolded rhodopsin in Drosophila", PLoS Genet. Aug 26;6(8). pii: e1001075.

Hauck SM, Dietter J, Kramer RL, Hofmaier F, Zipplies JK, Amann B, Feuchtinger A, Deeg CA, Ueffing M. (2010). "Deciphering membrane-associated molecular processes in target tissue of autoimmune uveitis by label-free quantitative mass spectrometry", Mol Cell Proteomics. 9:2292-305

Griciuc A, Aron L, Piccoli G, Ueffing M. (2010). "Clearance of Rhodopsin(P23H) aggregates requires the ERAD effector VCP", Biochim Biophys Acta. 2010 Mar;1803(3):424-34. Epub 2010 Jan 25.

Paquet-Durand F, Hauck SM, van Veen T, Ueffing M, Ekström P. "PKG activity causes photoreceptor cell death in two retinitis pigmentosa models", J Neurochem. 2009 Feb;108(3):796-810

Hauck SM, Gloeckner CJ, Harley ME, Schoeffmann S, Boldt K, Ekstrom PA, Ueffing M. "Identification of paracrine neuroprotective candidate proteins by a functional assay-driven proteomics approach", Mol Cell Proteomics. 2008 Jul;7(7):1349-61.

Deeg CA, Hauck SM, Amann B, Pompetzki D, Altmann F, Raith A, Schmalzl T, Stangassinger M, Ueffing M. "Equine recurrent uveitis--a spontaneous horse model of uveitis", Ophthalmic Res. 2008;40(3-4):151-3. Epub 2008 Apr 18. Review.

Paquet-Durand F, Silva J, Talukdar T, Johnson LE, Azadi S, van Veen T, Ueffing M, Hauck SM, Ekström PA. "Excessive activation of poly(ADP-ribose)polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse", J Neurosci. 2007 Sep 19;27(38):10311-9.

Swiatek-De Lange M, Stampfl A, Hauck SM, Zischka H, Gloeckner CJ, Deeg CA, Ueffing M. "Membrane- initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells", Glia. 2007 Aug 1;55(10):1061-73.

den Hollander AI, Koenekoop RK, Mohamed MD, Arts HH, Boldt K, Towns KV,Sedmak T, Beer M, Nagel- Wolfrum K, McKibbin M, Dharmaraj S, Lopez I, Ivings L,Williams GA, Springell K, Woods CG, Jafri H, Rashid Y, Strom TM, van der Zwaag B,Gosens I, Kersten FF, van Wijk E, Veltman JA, Zonneveld MN, van Beersum SE, Maumenee IH, Wolfrum U, Cheetham ME, Ueffing M, Cremers FP, Inglehearn CF, Roepman R. (2007). "Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis", Nat Genet. Jul;39:889-95.

Deeg CA, Hauck SM, Amann B, Kremmer E, Stangassinger M, Ueffing M. "Major retinal autoantigens remain stably expressed during all stages of spontaneous uveitis", Mol Immunol. 2007 Jul;44(13):3291-6.

Hauck SM, Schoeffmann S, Amann B, Stangassinger M, Gerhards H, Ueffing M, Deeg CA. "Retinal Mueller glial cells trigger the hallmark inflammatory process in autoimmune uveitis", J Proteome Res. 2007 Jun;6(6):2121-31.

Deeg CA, Altmann F, Hauck SM, Schoeffmann S, Amann B, Stangassinger M, Ueffing M. Down-regulation of pigment epithelium-derived factor in uveitic lesion associates with focal vascular endothelial growth factor expression and breakdown of the blood-retinal barrier. Proteomics. 2007 May;7(9):1540-8. den Hollander AI, et al., Ueffing M, Cremers FP, Inglehearn CF, Roepman R. (2007). "Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis", Nat Genet. Jul;39:889-95.

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